CEFR C1

bioactivation example

noun phrase

Meaning

A specific instance or case where a relatively inert compound is metabolized by an organism into a more biologically active, often toxic or therapeutic, form. This process is crucial in pharmacology and toxicology for understanding drug effects and chemical hazards.

Examples

  • A classic bioactivation example in toxicology is the conversion of parathion into paraoxon, a much more potent insecticide.
  • The liver's role in transforming certain prodrugs into their active therapeutic forms serves as a positive bioactivation example.

Synonyms: metabolic activation instance, prodrug conversion case, xenobiotic transformation case