acantholysis
noun
Meaning
Loss of intercellular connections between keratinocytes, leading to the formation of blisters in the skin.
Examples
- Pemphigus vulgaris is a serious autoimmune disease characterized by widespread acantholysis.
- The pathologist identified acantholysis in the tissue sample, which helped narrow down the diagnosis.
Synonyms: blistering, cell separation, desmosome loss, epidermal cleavage