acantholysis

noun

Meaning

Loss of intercellular connections between keratinocytes, leading to the formation of blisters in the skin.

Examples

  • Pemphigus vulgaris is a serious autoimmune disease characterized by widespread acantholysis.
  • The pathologist identified acantholysis in the tissue sample, which helped narrow down the diagnosis.

Synonyms: blistering, cell separation, desmosome loss, epidermal cleavage